Disorders of the thyroid gland

E4_THYROID

thyroid nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 E00-E07
Cause of death: ICD-10 E00-E07

22413

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

22393

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Check minimum number of events None

22393

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E4_THYROID

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 45450 36206 9244
Unadjusted prevalence (%) 14.73 20.86 6.85
Mean age at first event (years) 51.39 49.80 57.63

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.31 [1.16, 1.49] 3.0e-5 2969
15 years 0.01 0.91 [0.81, 1.03] 1.3e-1 1455
5 years 0.00 1.69 [1.50, 1.90] 1.5e-18 739
1 year 0.00 2.07 [1.72, 2.50] 3.7e-14 170

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_THYROID – Disorders of the thyroid gland
GWS hits: 58

Survival analyses between endpoints

Plot

before Disorders of the thyroid gland
after Disorders of the thyroid gland

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of the thyroid gland