Disorders of the thyroid gland

E4_THYROID

thyroid nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E00-E07

Cause of death: ICD-10 E00-E07

22413

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

22393

Check minimum number of events None

22393

Include endpoints

E4_CONGEIOD

E4_IODGOITRE

E4_IODTHYR

E4_IODHYPSUB

E4_HYTHYSUBS

E4_HYTHYPOSTINF

E4_ATROTHY

E4_MYXOCO

E4_HYTHYNAS

E4_GOITREDIFF

E4_GOITRENOD

E4_GOITREMULTINOD

E4_GOITRENAS

E4_THYTOXGOITDIF

E4_THYTOXECT

E4_THYCRISIS

E4_THYTOXNAS

E4_THYROIDITACU

E4_THYROIDITSUBAC

E4_THYROIDITCHRON

E4_THYROIDITAUTOIM

E4_THYROIDITDRUG

E4_THYROIDITNAS

E4_HYPERSECCAL

E4_GOITREDYS

E4_THYROIDNASOTH

46935

E4_THYROID

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Disorders of the thyroid gland based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	45450	36206	9244
Unadjusted prevalence (%)	14.73	20.86	6.85
Mean age at first event (years)	51.39	49.80	57.63

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.31 [1.16, 1.49]	3.0e-5	2969
15 years	0.01	0.91 [0.81, 1.03]	1.3e-1	1455
5 years	0.00	1.69 [1.50, 1.90]	1.5e-18	739
1 year	0.00	2.07 [1.72, 2.50]	3.7e-14	170

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYROID – Disorders of the thyroid gland
GWS hits: 58

Survival analyses between endpoints

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Plot

before Disorders of the thyroid gland
after Disorders of the thyroid gland

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Table

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Drugs most likely to be purchased after Disorders of the thyroid gland

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