Thyrotoxicosis, other and/or unspecified


Thyrotoxicosis: A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E05[4-9]
Hospital discharge: ICD-9 2423
Hospital discharge: ICD-8 2422
Cause of death: ICD-10 E05[4-9]
Cause of death: ICD-9 2423
Cause of death: ICD-8 2422
Medicine purchases: ATC H03B


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events

Min. number of events 3


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 4703 3720 983
Unadjusted prevalence (%) 1.52 2.14 0.73
Mean age at first event (years) 52.54 51.24 57.43


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.69 [1.80, 4.02] 1.4e-6 263
15 years 0.01 1.56 [1.12, 2.18] 8.2e-3 117
5 years 0.00 2.93 [2.11, 4.05] 1.0e-10 84
1 year 0.00 5.77 [3.81, 8.73] 1.1e-16 34

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_THYTOXNAS – Thyrotoxicosis, other and/or unspecified
GWS hits: 13

Survival analyses between endpoints


before Thyrotoxicosis, other and/or unspecified
after Thyrotoxicosis, other and/or unspecified

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Drugs most likely to be purchased after Thyrotoxicosis, other and/or unspecified