Thyrotoxicosis, other and/or unspecified

E4_THYTOXNAS

Thyrotoxicosis: A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E05[4-9]

Hospital discharge: ICD-9 2423

Hospital discharge: ICD-8 2422

Cause of death: ICD-10 E05[4-9]

Cause of death: ICD-9 2423

Cause of death: ICD-8 2422

Medicine purchases: ATC H03B

5754

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4863

Check minimum number of events

Min. number of events 3

4863

Include endpoints None

4863

E4_THYTOXNAS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Thyrotoxicosis, other and/or unspecified based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

4703

3720

983

Unadjusted prevalence (%)

1.52

2.14

0.73

Mean age at first event (years)

52.54

51.24

57.43

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Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.69 [1.80, 4.02]	1.4e-6	263
15 years	0.01	1.56 [1.12, 2.18]	8.2e-3	117
5 years	0.00	2.93 [2.11, 4.05]	1.0e-10	84
1 year	0.00	5.77 [3.81, 8.73]	1.1e-16	34

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXNAS – Thyrotoxicosis, other and/or unspecified
GWS hits: 13

Survival analyses between endpoints

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Plot

before Thyrotoxicosis, other and/or unspecified
after Thyrotoxicosis, other and/or unspecified

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Table

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Drugs most likely to be purchased after Thyrotoxicosis, other and/or unspecified

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