Congenital iodine-deficiency syndrome/hypothyroidism

DOID EFO MESH SNOMED PheWeb

E4_CONGEIOD

thyroid disease: A disease involving the thyroid gland.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E00, E03.0, E03.1

Hospital discharge: ICD-9 243

Hospital discharge: ICD-8 243

Cause of death: ICD-10 E00, E03.0, E03.1

Cause of death: ICD-9 243

Cause of death: ICD-8 243

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

753

E4_CONGEIOD

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Congenital iodine-deficiency syndrome/hypothyroidism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	734	592	142
Unadjusted prevalence (%)	0.24	0.34	0.11
Mean age at first event (years)	55.63	54.53	60.24

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.64 [0.41, 6.50]	4.8e-1	93
15 years	0.00	0.74 [0.23, 2.30]	6.0e-1	27
5 years	0.00	3.15 [1.44, 6.91]	4.1e-3	38
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism
GWS hits: 3

Survival analyses between endpoints

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Plot

before Congenital iodine-deficiency syndrome/hypothyroidism
after Congenital iodine-deficiency syndrome/hypothyroidism

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Table

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Drugs most likely to be purchased after Congenital iodine-deficiency syndrome/hypothyroidism

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