Nontoxic single thyroid nodule

DOID EFO MESH SNOMED PheWeb

E4_GOITRENOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E04.1

Hospital discharge: ICD-9 2410|2462

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E04.1

Cause of death: ICD-9 2410|2462

Cause of death: ICD-8 $!$

1754

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1692

Check minimum number of events None

1692

Include endpoints None

1692

E4_GOITRENOD

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E04

Name in latin Struma atoxica uninodularis

Similar endpoints

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List of similar endpoints to Nontoxic single thyroid nodule based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1634	1327	307
Unadjusted prevalence (%)	0.53	0.76	0.23
Mean age at first event (years)	50.81	49.37	57.04

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.77 [0.42, 1.40]	3.9e-1	63
15 years	0.00	0.51 [0.27, 0.98]	4.3e-2	29
5 years	0.00	0.93 [0.43, 2.01]	8.5e-1	11
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule
GWS hits: 1

Survival analyses between endpoints

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Plot

before Nontoxic single thyroid nodule
after Nontoxic single thyroid nodule

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Table

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Drugs most likely to be purchased after Nontoxic single thyroid nodule

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