Nontoxic multinodular goitre

DOID EFO MESH SNOMED PheWeb

E4_GOITREMULTINOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E04.2

Hospital discharge: ICD-9 2411

Hospital discharge: ICD-8 241

Cause of death: ICD-10 E04.2

Cause of death: ICD-9 2411

Cause of death: ICD-8 241

5494

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5090

Check minimum number of events None

5090

Include endpoints None

5090

E4_GOITREMULTINOD

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E04

Name in latin Struma atoxica multinodularis

Similar endpoints

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List of similar endpoints to Nontoxic multinodular goitre based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4933	4204	729
Unadjusted prevalence (%)	1.60	2.42	0.54
Mean age at first event (years)	52.17	51.12	58.24

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.79 [0.57, 1.08]	1.4e-1	353
15 years	0.00	0.59 [0.42, 0.82]	1.6e-3	172
5 years	0.00	1.00 [0.71, 1.41]	1.0e+0	70
1 year	0.00	1.18 [0.67, 2.08]	5.6e-1	15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITREMULTINOD – Nontoxic multinodular goitre
GWS hits: 29

Survival analyses between endpoints

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Plot

before Nontoxic multinodular goitre
after Nontoxic multinodular goitre

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Table

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Drugs most likely to be purchased after Nontoxic multinodular goitre

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