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Autoimmune thyroiditis

DOIDEFOMESH PheWeb

E4_THYROIDITAUTOIM

autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 E06.3
Hospital discharge: ICD-9 2452
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E06.3
Cause of death: ICD-9 2452
Cause of death: ICD-8 $!$

373

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

373

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Check minimum number of events None

373

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Include endpoints None

373

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E4_THYROIDITAUTOIM

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E06
Name in latin Thyreoiditis autoimmunis

Summary Statistics

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Key figures

All Female Male
Number of individuals 366 313 53
Unadjusted prevalence (%) 0.12 0.18 0.04
Mean age at first event (years) 41.81 41.00 46.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.76 [1.43, 5.34] 2.5e-3 13
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis
GWS hits: 2

Survival analyses between endpoints

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Plot

before Autoimmune thyroiditis
after Autoimmune thyroiditis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Autoimmune thyroiditis

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