Hypothyroidism, other/unspecified

DOID EFO MESH SNOMED PheWeb

E4_HYTHYNAS

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E03.80, E03.82, E03.89, E03.9, E03.9+F02.89, E03.9+G13.2, E03.9+M14.5

Hospital discharge: ICD-9 244[8-9]

Hospital discharge: ICD-8 244

Hospital discharge: excluded ICD-9 2448A|2448B

Hospital discharge: excluded ICD-8 24409

Cause of death: ICD-10 E03.80, E03.82, E03.89, E03.9, E03.9+F02.89, E03.9+G13.2, E03.9+M14.5

Cause of death: ICD-9 244[8-9]

Cause of death: ICD-8 244

Cause of death: excluded ICD-9 2448A|2448B

KELA reimbursements: KELA codes 104

KELA reimbursements: ICD-10 E03

Medicine purchases: ATC H03A

43093

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

39804

Check minimum number of events

Min. number of events 3

39804

Include endpoints None

39804

E4_HYTHYNAS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Hypothyroidism, other/unspecified based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	38554	30907	7647
Unadjusted prevalence (%)	12.50	17.81	5.66
Mean age at first event (years)	52.05	50.54	58.17

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.47 [1.28, 1.70]	1.3e-7	2418
15 years	0.01	1.00 [0.88, 1.14]	9.9e-1	1216
5 years	0.00	1.79 [1.58, 2.03]	1.3e-20	625
1 year	0.00	1.74 [1.40, 2.17]	6.7e-7	112

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYTHYNAS – Hypothyroidism, other/unspecified
GWS hits: 87

Survival analyses between endpoints

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Plot

before Hypothyroidism, other/unspecified
after Hypothyroidism, other/unspecified

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Table

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Drugs most likely to be purchased after Hypothyroidism, other/unspecified

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