Hypothyroidism, levothyroxin purchases


hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Medicine purchases: ATC H03AA01


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Check pre-conditions, main-only, mode, ICD version None


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Check minimum number of events

Min. number of events 3


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Hypothyroidism, levothyroxin purchases based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 38127 30611 7516
Unadjusted prevalence (%) 12.36 17.64 5.57
Mean age at first event (years) 52.14 50.65 58.21


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.35 [1.17, 1.57] 4.9e-5 2355
15 years 0.01 0.96 [0.84, 1.09] 5.4e-1 1211
5 years 0.00 1.73 [1.52, 1.96] 6.3e-17 602
1 year 0.00 1.33 [1.04, 1.70] 2.2e-2 84

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: HYPOTHY_LEVOTHY – Hypothyroidism, levothyroxin purchases
GWS hits: 37

Survival analyses between endpoints


before Hypothyroidism, levothyroxin purchases
after Hypothyroidism, levothyroxin purchases

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Drugs most likely to be purchased after Hypothyroidism, levothyroxin purchases