Hypothyroidism, levothyroxin purchases

DOID EFO MESH SNOMED PheWeb

HYPOTHY_LEVOTHY

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Medicine purchases: ATC H03AA01

42784

Check pre-conditions, main-only, mode, ICD version None

39361

Check minimum number of events

Min. number of events 3

39361

Include endpoints None

39361

HYPOTHY_LEVOTHY

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Hypothyroidism, levothyroxin purchases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	38127	30611	7516
Unadjusted prevalence (%)	12.36	17.64	5.57
Mean age at first event (years)	52.14	50.65	58.21

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.35 [1.17, 1.57]	4.9e-5	2355
15 years	0.01	0.96 [0.84, 1.09]	5.4e-1	1211
5 years	0.00	1.73 [1.52, 1.96]	6.3e-17	602
1 year	0.00	1.33 [1.04, 1.70]	2.2e-2	84

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: HYPOTHY_LEVOTHY – Hypothyroidism, levothyroxin purchases
GWS hits: 37

Survival analyses between endpoints

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Plot

before Hypothyroidism, levothyroxin purchases
after Hypothyroidism, levothyroxin purchases

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Table

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Drugs most likely to be purchased after Hypothyroidism, levothyroxin purchases

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