Hypothyroidism, strict autoimmune, 3 medication purchases required

PheWeb

E4_HYTHY_AI_STRICT_PURCH

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

HYPOTHY_PURCHASE

39361

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

E4_HYTHY_AI_STRICT

34122

E4_HYTHY_AI_STRICT_PURCH

Extra metadata

First used in FinnGen datafreeze DF5

Similar endpoints

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List of similar endpoints to Hypothyroidism, strict autoimmune, 3 medication purchases required based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	33059	26596	6463
Unadjusted prevalence (%)	10.71	15.33	4.79
Mean age at first event (years)	52.14	50.52	58.80

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.28 [1.10, 1.49]	1.9e-3	2119
15 years	0.01	0.93 [0.81, 1.06]	2.9e-1	1089
5 years	0.00	1.72 [1.51, 1.97]	4.5e-16	546
1 year	0.00	1.31 [1.01, 1.69]	4.0e-2	75

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYTHY_AI_STRICT_PURCH – Hypothyroidism, strict autoimmune, 3 medication purchases required
GWS hits: 88

Survival analyses between endpoints

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Plot

before Hypothyroidism, strict autoimmune, 3 medication purchases required
after Hypothyroidism, strict autoimmune, 3 medication purchases required

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Table

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Drugs most likely to be purchased after Hypothyroidism, strict autoimmune, 3 medication purchases required

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