Type1 diabetes, definitions combined

T1D

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

not E4_DM2

270311

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

3807

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T1D

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Type1 diabetes, definitions combined based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 3711 1831 1880
Unadjusted prevalence (%) 1.20 1.06 1.39
Mean age at first event (years) 18.86 17.85 19.83

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.20 [1.54, 6.65] 1.9e-3 154
15 years 0.01 2.55 [1.27, 5.12] 8.7e-3 65
5 years 0.01 5.47 [2.86, 10.46] 2.8e-7 33
1 year 0.00 17.64 [9.16, 33.96] 9.2e-18 21

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: T1D – Type1 diabetes, definitions combined
GWS hits: 23

Survival analyses between endpoints

Plot

before Type1 diabetes, definitions combined
after Type1 diabetes, definitions combined

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Drugs most likely to be purchased after Type1 diabetes, definitions combined