Type 1 diabetes, strict (exclude DM2)

E4_DM1_STRICT

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

not E4_DM2

270311

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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E4_DM1_STRICT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 3678 1812 1866
Unadjusted prevalence (%) 1.19 1.04 1.38
Mean age at first event (years) 20.60 19.65 21.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 6.34 [3.59, 11.21] 2.1e-10 153
15 years 0.03 4.19 [2.40, 7.31] 4.6e-7 63
5 years 0.01 8.60 [5.23, 14.15] 2.5e-17 33
1 year 0.00 27.50 [16.23, 46.60] 7.4e-35 22

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DM1_STRICT – Type 1 diabetes, strict (exclude DM2)
GWS hits: 20

Survival analyses between endpoints

Plot

before Type 1 diabetes, strict (exclude DM2)
after Type 1 diabetes, strict (exclude DM2)

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Drugs most likely to be purchased after Type 1 diabetes, strict (exclude DM2)