Type 1 diabetes, strict definition, subgroup 2

T1D_STRICT2

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not E4_DM2

and not PANCREATITIS

and not INSULIN_INTER_AND_LONG

and KELA_DIAB_INSUL

and INSULIN_SHORTFAST

104

Filter registries None

Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE<40

Check minimum number of events None

Include endpoints

T1D_ICD9_10

T1D_STRICT2

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Type 1 diabetes, strict definition, subgroup 2 based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	71	31	40
Unadjusted prevalence (%)	0.02	0.02	0.03
Mean age at first event (years)	15.68	14.30	16.75

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D_STRICT2 – Type 1 diabetes, strict definition, subgroup 2
GWS hits:

Survival analyses between endpoints

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Plot

before Type 1 diabetes, strict definition, subgroup 2
after Type 1 diabetes, strict definition, subgroup 2

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Table

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Drugs most likely to be purchased after Type 1 diabetes, strict definition, subgroup 2

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