Type 1 diabetes, strict definition, subgroup 1

DOID EFO MESH SNOMED PheWeb

T1D_STRICT1

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not E4_DM2

and not PANCREATITIS

and KELA_DIAB_INSUL

and INSULIN_SHORTFAST

and INSULIN_INTER_AND_LONG

3336

Filter registries None

Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE<40

Check minimum number of events None

Include endpoints

T1D_ICD9_10

3004

T1D_STRICT1

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Type 1 diabetes, strict definition, subgroup 1 based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2938	1472	1466
Unadjusted prevalence (%)	0.95	0.85	1.09
Mean age at first event (years)	15.15	14.74	15.56

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.40 [3.41, 12.01]	7.3e-9	46
15 years	0.04	6.68 [3.40, 13.10]	3.4e-8	24
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D_STRICT1 – Type 1 diabetes, strict definition, subgroup 1
GWS hits: 23

Survival analyses between endpoints

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Plot

before Type 1 diabetes, strict definition, subgroup 1
after Type 1 diabetes, strict definition, subgroup 1

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Table

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Drugs most likely to be purchased after Type 1 diabetes, strict definition, subgroup 1

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