Type 1 diabetes, wide definition

DOID EFO MESH SNOMED PheWeb

T1D_WIDE

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

T1D_WIDE1

T1D_WIDE2

D1_ICD8

7518

T1D_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Type 1 diabetes, wide definition based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7337	3567	3770
Unadjusted prevalence (%)	2.38	2.06	2.79
Mean age at first event (years)	26.78	25.06	28.41

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.66 [2.00, 3.54]	2.4e-11	650
15 years	0.01	1.85 [1.45, 2.37]	7.4e-7	306
5 years	0.00	1.04 [0.71, 1.53]	8.3e-1	36
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D_WIDE – Type 1 diabetes, wide definition
GWS hits: 33

Survival analyses between endpoints

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Plot

before Type 1 diabetes, wide definition
after Type 1 diabetes, wide definition

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Table

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Drugs most likely to be purchased after Type 1 diabetes, wide definition

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