Type 1 diabetes with neurological complications

E4_DM1NEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E10.4+, E10.4+G59.0, E10.4+G63.2, E10.4+G73.0, E10.4+G99.0

Hospital discharge: ICD-9 2505B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E10.4+, E10.4+G59.0, E10.4+G63.2, E10.4+G73.0, E10.4+G99.0

Cause of death: ICD-9 2505B

Cause of death: ICD-8 $!$

883

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

883

Check minimum number of events None

883

Include endpoints None

883

E4_DM1NEU

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Type 1 diabetes with neurological complications based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	867	400	467
Unadjusted prevalence (%)	0.28	0.23	0.35
Mean age at first event (years)	45.92	43.83	47.72

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.09	6.91 [4.77, 10.01]	1.4e-24	148
15 years	0.03	3.99 [2.74, 5.80]	4.4e-13	66
5 years	0.01	7.32 [4.65, 11.53]	9.1e-18	43
1 year	0.00	10.56 [5.51, 20.25]	1.2e-12	13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1NEU – Type 1 diabetes with neurological complications
GWS hits: 9

Survival analyses between endpoints

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Plot

before Type 1 diabetes with neurological complications
after Type 1 diabetes with neurological complications

Loading survival analyses plot

Table

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Drugs most likely to be purchased after Type 1 diabetes with neurological complications

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