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Diabetic neuropathy

DOIDEFOMESHSNOMED PheWeb

DM_NEUROPATHY

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 E1[0-4]4
Hospital discharge: ICD-9 2505
Hospital discharge: ICD-8 25005
Cause of death: ICD-10 E1[0-4]4
Cause of death: ICD-9 2505
Cause of death: ICD-8 25005

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints

2259

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DM_NEUROPATHY

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diabetic neuropathy based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 2206 819 1387
Unadjusted prevalence (%) 0.71 0.47 1.03
Mean age at first event (years) 56.21 53.85 57.60

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.81 [2.57, 5.66] 3.3e-11 578
15 years 0.01 2.19 [1.63, 2.96] 2.6e-7 255
5 years 0.00 4.10 [3.20, 5.25] 4.2e-29 168
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_NEUROPATHY – Diabetic neuropathy
GWS hits: 1

Survival analyses between endpoints

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Plot

before Diabetic neuropathy
after Diabetic neuropathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic neuropathy

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