Type 1 diabetes

DOID EFO MESH SNOMED PheWeb

E4_DM1

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E10

Cause of death: ICD-10 E10

8451

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

8451

Check minimum number of events None

8451

Include endpoints

E4_DM1COMA

E4_DM1KETO

E4_DM1REN

E4_DM1OPTH

E4_DM1NEU

E4_DM1PERIPH

E4_DM1NASCOMP

E4_DM1NOCOMP

8900

E4_DM1

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E10-E14

Name in latin Diabetes (mellitus) juvenilis

Similar endpoints

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List of similar endpoints to Type 1 diabetes based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	8671	4049	4622
Unadjusted prevalence (%)	2.81	2.33	3.42
Mean age at first event (years)	33.30	30.89	35.41

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	5.40 [4.35, 6.71]	1.7e-52	1135
15 years	0.02	3.20 [2.67, 3.83]	2.9e-36	513
5 years	0.00	4.91 [4.09, 5.88]	2.3e-66	275
1 year	0.00	9.30 [7.34, 11.78]	5.8e-76	112

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1 – Type 1 diabetes
GWS hits: 30

Survival analyses between endpoints

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Plot

before Type 1 diabetes
after Type 1 diabetes

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Table

Loading survival analyses table

Drugs most likely to be purchased after Type 1 diabetes

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