Type 1 diabetes with renal complications

MESH PheWeb

E4_DM1REN

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E10.2+, E10.2+N08.39

Hospital discharge: ICD-9 2503B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E10.2+, E10.2+N08.39

Cause of death: ICD-9 2503B

Cause of death: ICD-8 $!$

1376

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1376

Check minimum number of events None

1376

Include endpoints None

1376

E4_DM1REN

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Type 1 diabetes with renal complications based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1342	582	760
Unadjusted prevalence (%)	0.43	0.34	0.56
Mean age at first event (years)	41.96	38.51	44.60

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.80 [1.38, 16.75]	1.4e-2	247
15 years	0.02	3.20 [1.10, 9.30]	3.3e-2	97
5 years	0.01	11.62 [5.52, 24.44]	1.0e-10	92
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1REN – Type 1 diabetes with renal complications
GWS hits: 7

Survival analyses between endpoints

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Plot

before Type 1 diabetes with renal complications
after Type 1 diabetes with renal complications

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Table

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Drugs most likely to be purchased after Type 1 diabetes with renal complications

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