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Diabetic nephropathy

DOIDEFOMESHSNOMED PheWeb

DM_NEPHROPATHY

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 N08.3*
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 N08.3*
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1792

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1792

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Check minimum number of events None

1792

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Include endpoints

3353

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DM_NEPHROPATHY

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 3256 1176 2080
Unadjusted prevalence (%) 1.06 0.68 1.54
Mean age at first event (years) 53.87 48.72 56.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 7.59 [4.92, 11.72] 5.0e-20 880
15 years 0.02 3.20 [2.17, 4.70] 3.4e-9 301
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_NEPHROPATHY – Diabetic nephropathy
GWS hits: 7

Survival analyses between endpoints

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Plot

before Diabetic nephropathy
after Diabetic nephropathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic nephropathy

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