Systemic connective tissue disorders

M13_SYSTCONNECT

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Systemic connective tissue disorders based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 8992 6527 2465
Unadjusted prevalence (%) 2.91 3.76 1.83
Mean age at first event (years) 54.94 52.84 60.50

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.25 [1.49, 3.39] 1.1e-4 943
15 years 0.01 1.28 [0.94, 1.75] 1.1e-1 387
5 years 0.00 2.84 [2.31, 3.49] 6.7e-23 294
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_SYSTCONNECT – Systemic connective tissue disorders
GWS hits: 3

Survival analyses between endpoints

Plot

before Systemic connective tissue disorders
after Systemic connective tissue disorders

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Drugs most likely to be purchased after Systemic connective tissue disorders