Systemic connective tissue disorders

M13_SYSTCONNECT

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

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M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Systemic connective tissue disorders based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 8992 6527 2465
Unadjusted prevalence (%) 2.91 3.76 1.83
Mean age at first event (years) 54.94 52.84 60.50

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.25 [1.49, 3.39] 1.1e-4 943
15 years 0.01 1.28 [0.94, 1.75] 1.1e-1 387
5 years 0.00 2.84 [2.31, 3.49] 6.7e-23 294
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SYSTCONNECT – Systemic connective tissue disorders
GWS hits: 3

Survival analyses between endpoints

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Plot

before Systemic connective tissue disorders
after Systemic connective tissue disorders

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Drugs most likely to be purchased after Systemic connective tissue disorders

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