Systemic sclerosis

M13_SYSTSLCE

systemic scleroderma: A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M34

Hospital discharge: ICD-9 7101

Hospital discharge: ICD-8 7340

Cause of death: ICD-10 M34

Cause of death: ICD-9 7101

Cause of death: ICD-8 7340

561

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

496

Check minimum number of events None

496

Include endpoints None

496

M13_SYSTSLCE

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M30-M36

Name in latin Sclerosis systemica

Similar endpoints

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List of similar endpoints to Systemic sclerosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	482	396	86
Unadjusted prevalence (%)	0.16	0.23	0.06
Mean age at first event (years)	54.24	54.19	54.44

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.76 [1.11, 6.87]	3.0e-2	37
15 years	0.01	1.32 [0.54, 3.19]	5.4e-1	12
5 years	0.00	4.18 [1.97, 8.83]	1.9e-4	13
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SYSTSLCE – Systemic sclerosis
GWS hits: 0

Survival analyses between endpoints

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Plot

before Systemic sclerosis
after Systemic sclerosis

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Table

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Drugs most likely to be purchased after Systemic sclerosis

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