Systemic sclerosis


systemic scleroderma: A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M34
Hospital discharge: ICD-9 7101
Hospital discharge: ICD-8 7340
Cause of death: ICD-10 M34
Cause of death: ICD-9 7101
Cause of death: ICD-8 7340


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M30-M36
Name in latin Sclerosis systemica

Summary Statistics

Key figures

All Female Male
Number of individuals 482 396 86
Unadjusted prevalence (%) 0.16 0.23 0.06
Mean age at first event (years) 54.24 54.19 54.44


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.76 [1.11, 6.87] 3.0e-2 37
15 years 0.01 1.32 [0.54, 3.19] 5.4e-1 12
5 years 0.00 4.18 [1.97, 8.83] 1.9e-4 13
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_SYSTSLCE – Systemic sclerosis
GWS hits: 0

Survival analyses between endpoints


before Systemic sclerosis
after Systemic sclerosis

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Drugs most likely to be purchased after Systemic sclerosis