Sicca syndrome [Sjögren]

M13_SJOGREN

Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M35.0

Hospital discharge: ICD-9 7102

Hospital discharge: ICD-8 73490

Cause of death: ICD-10 M35.0

Cause of death: ICD-9 7102

Cause of death: ICD-8 73490

2035

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2035

Check minimum number of events None

2035

Include endpoints None

2035

M13_SJOGREN

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M35

Name in latin Syndroma Sjögren

Similar endpoints

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List of similar endpoints to Sicca syndrome [Sjögren] based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1981	1722	259
Unadjusted prevalence (%)	0.64	0.99	0.19
Mean age at first event (years)	53.21	52.63	57.06

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.92 [1.14, 3.25]	1.5e-2	131
15 years	0.01	1.54 [0.96, 2.45]	7.3e-2	69
5 years	0.00	2.31 [1.44, 3.69]	4.9e-4	28
1 year	0.00	6.42 [3.59, 11.47]	3.5e-10	15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 4

Survival analyses between endpoints

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Plot

before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

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Table

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Drugs most likely to be purchased after Sicca syndrome [Sjögren]

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