Systemic lupus erythematosus

M13_SLE

systemic lupus erythematosus: An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M32

Hospital discharge: ICD-9 7100

Hospital discharge: ICD-8 7431

Cause of death: ICD-10 M32

Cause of death: ICD-9 7100

Cause of death: ICD-8 7431

991

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

863

Check minimum number of events None

863

Include endpoints None

863

M13_SLE

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M30-M36

Name in latin Lupus erythematosus disseminatus (LED)

Similar endpoints

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List of similar endpoints to Systemic lupus erythematosus based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	835	696	139
Unadjusted prevalence (%)	0.27	0.40	0.10
Mean age at first event (years)	45.45	44.62	49.64

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.32 [4.05, 9.84]	3.9e-16	72
15 years	0.02	3.62 [2.33, 5.64]	1.2e-8	31
5 years	0.01	4.90 [2.76, 8.69]	5.4e-8	16
1 year	0.00	18.53 [9.47, 36.23]	1.4e-17	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SLE – Systemic lupus erythematosus
GWS hits: 3

Survival analyses between endpoints

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Plot

before Systemic lupus erythematosus
after Systemic lupus erythematosus

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Table

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Drugs most likely to be purchased after Systemic lupus erythematosus

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