Polyarteritis nodosa and related conditions

M13_POLYARTERETAL

Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M30
Cause of death: ICD-10 M30

287

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

287

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Check minimum number of events None

287

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M13_POLYARTERETAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M30-M36
Name in latin Polyarteritis nodosa et condiciones cognatae

Similar endpoints

List of similar endpoints to Polyarteritis nodosa and related conditions based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 295 176 119
Unadjusted prevalence (%) 0.10 0.10 0.09
Mean age at first event (years) 48.44 47.62 49.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 7.22 [4.37, 11.95] 1.4e-14 42
15 years 0.01 2.33 [1.26, 4.31] 6.8e-3 13
5 years 0.01 4.79 [2.43, 9.42] 5.8e-6 14
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_POLYARTERETAL – Polyarteritis nodosa and related conditions
GWS hits:

Survival analyses between endpoints

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Drugs most likely to be purchased after Polyarteritis nodosa and related conditions