Polyarteritis with lung involvement [Churg-Strauss]/EGPA

M13_CHURGSTRAUSS

Churg-Strauss syndrome: Eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome, is a systemic vasculitis of small-to medium vessels, characterized by asthma, transient pulmonary infiltrates, and hypereosinophilia.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M30.1

Hospital discharge: ICD-9 4460B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M30.1

Cause of death: ICD-9 4460B

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

M13_CHURGSTRAUSS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M30

Name in latin Polyarteritis nodosa cum manifestationibus pulmonalibus

Similar endpoints

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List of similar endpoints to Polyarteritis with lung involvement [Churg-Strauss]/EGPA based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

Unadjusted prevalence (%)

0.03

0.02

Mean age at first event (years)

49.98

50.00

49.95

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_CHURGSTRAUSS – Polyarteritis with lung involvement [Churg-Strauss]/EGPA
GWS hits:

Survival analyses between endpoints

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Plot

before Polyarteritis with lung involvement [Churg-Strauss]/EGPA
after Polyarteritis with lung involvement [Churg-Strauss]/EGPA

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Table

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Drugs most likely to be purchased after Polyarteritis with lung involvement [Churg-Strauss]/EGPA

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