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Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium

DOIDEFOMESHSNOMED PheWeb

O15_OEDEM_PROTUR_HYPERT

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule

Sex only females

180574

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Check conditions None

180574

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Filter registries

Hospital Discharge: ICD-10 O10-O16
Hospital discharge: ICD-9 642
Hospital discharge: ICD-8 637
Cause of death: ICD-10 O10-O16
Cause of death: ICD-9 642
Cause of death: ICD-8 637

14143

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

13195

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Check minimum number of events None

13195

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Include endpoints

13436

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O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF5

Similar endpoints

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List of similar endpoints to Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 13076 13076 -
Unadjusted prevalence (%) 4.24 7.54 -
Mean age at first event (years) 29.38 29.38 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.70 [0.55, 0.89] 3.6e-3 227
15 years 0.00 0.56 [0.42, 0.74] 4.7e-5 92
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_OEDEM_PROTUR_HYPERT – Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
GWS hits: 6

Survival analyses between endpoints

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Plot

before Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
after Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium

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Drugs most likely to be purchased after Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium

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