Pre-eclampsia or eclampsia


preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule

Sex only females


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 O11, O14, O15.0, O15.1, O15.2
Hospital discharge: ICD-9 642[4-7]
Hospital discharge: ICD-8 6370[349]|63710|63799|66120
Cause of death: ICD-10 O11, O14, O15.0, O15.1, O15.2
Cause of death: ICD-9 642[4-7]
Cause of death: ICD-8 6370[349]|63710|63799|66120


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 5731 5731 -
Unadjusted prevalence (%) 1.86 3.30 -
Mean age at first event (years) 29.05 29.05 -


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.61 [0.45, 0.84] 2.4e-3 91
15 years 0.00 0.41 [0.27, 0.63] 3.9e-5 31
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: O15_PRE_OR_ECLAMPSIA – Pre-eclampsia or eclampsia
GWS hits: 0

Survival analyses between endpoints


before Pre-eclampsia or eclampsia
after Pre-eclampsia or eclampsia

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Drugs most likely to be purchased after Pre-eclampsia or eclampsia