Pre-eclampsia or eclampsia

O15_PRE_OR_ECLAMPSIA

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule

Sex only females

180574

Check conditions None

180574

Filter registries

Hospital Discharge: ICD-10 O11, O14, O15.0, O15.1, O15.2

Hospital discharge: ICD-9 642[4-7]

Hospital discharge: ICD-8 6370[349]|63710|63799|66120

Cause of death: ICD-10 O11, O14, O15.0, O15.1, O15.2

Cause of death: ICD-9 642[4-7]

Cause of death: ICD-8 6370[349]|63710|63799|66120

5908

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5908

Check minimum number of events None

5908

Include endpoints None

5908

O15_PRE_OR_ECLAMPSIA

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Pre-eclampsia or eclampsia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Pre-eclampsia superimposed on chronic hypertension

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5731	5731	-
Unadjusted prevalence (%)	1.86	3.30	-
Mean age at first event (years)	29.05	29.05	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.61 [0.45, 0.84]	2.4e-3	91
15 years	0.00	0.41 [0.27, 0.63]	3.9e-5	31
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_PRE_OR_ECLAMPSIA – Pre-eclampsia or eclampsia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Pre-eclampsia or eclampsia
after Pre-eclampsia or eclampsia

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Pre-eclampsia or eclampsia

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