Pregnancy hypertension

O15_HYPTENSPREG

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule

Sex only females

180574

Check conditions None

180574

Filter registries

Hospital Discharge: ICD-10 O10, O11, O13, O14, O15, O16

Hospital discharge: ICD-9 642

Hospital discharge: ICD-8 63701|63703|63704|63709|63710|63799|66120

Cause of death: ICD-10 O10, O11, O13, O14, O15, O16

Cause of death: ICD-9 642

Cause of death: ICD-8 63701|63703|63704|63709|63710|63799

11874

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

11841

Check minimum number of events None

11841

Include endpoints None

11841

O15_HYPTENSPREG

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF3

Similar endpoints

↥

List of similar endpoints to Pregnancy hypertension based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	11534	11534	-
Unadjusted prevalence (%)	3.74	6.65	-
Mean age at first event (years)	29.65	29.65	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.75 [0.59, 0.97]	2.7e-2	193
15 years	0.00	0.61 [0.45, 0.82]	1.0e-3	79
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: O15_HYPTENSPREG – Pregnancy hypertension
GWS hits: 8

Survival analyses between endpoints

↥

Plot

before Pregnancy hypertension
after Pregnancy hypertension

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Pregnancy hypertension

↥