Pre-eclampsia

O15_PREECLAMPS

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule

Sex only females

180574

Check conditions None

180574

Filter registries

Hospital Discharge: ICD-10 O14

Hospital discharge: ICD-9 642[4-5]

Hospital discharge: ICD-8 6370[349]

Cause of death: ICD-10 O14

Cause of death: ICD-9 642[4-5]

Cause of death: ICD-8 6370[349]

5434

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5434

Check minimum number of events None

5434

Include endpoints None

5434

O15_PREECLAMPS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF5

Parent code in ICD-10 O10-O16

Name in latin Hypertensio gestationalis cum proteinuria significanti

Similar endpoints

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List of similar endpoints to Pre-eclampsia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5265	5265	-
Unadjusted prevalence (%)	1.71	3.03	-
Mean age at first event (years)	29.08	29.08	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.67 [0.46, 0.98]	3.9e-2	79
15 years	0.00	0.46 [0.28, 0.74]	1.4e-3	27
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_PREECLAMPS – Pre-eclampsia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Pre-eclampsia
after Pre-eclampsia

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Pre-eclampsia

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