Hypertension complicating pregnancy, childbirth, and the puerperium

I9_HYPTENSPREG

HELLP syndrome: HELLP syndrome is a life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia . If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also includemedications needed for the mother or baby, and blood transfusion for severe bleeding problems.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule

Sex only females

180574

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Check conditions None

180574

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Filter registries

Hospital Discharge: ICD-10 O10, O11, O13, O14, O15, O16
Hospital discharge: ICD-9 642
Hospital discharge: ICD-8 63701|63703|63704|63709|63710|63799
Cause of death: ICD-10 O10, O11, O13, O14, O15, O16
Cause of death: ICD-9 642
Cause of death: ICD-8 63701|63703|63704|63709|63710|63799

11781

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

11748

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Check minimum number of events None

11748

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Include endpoints None

11748

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I9_HYPTENSPREG

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Hypertension complicating pregnancy, childbirth, and the puerperium based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 11443 11443 -
Unadjusted prevalence (%) 3.71 6.59 -
Mean age at first event (years) 29.67 29.67 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.70 [0.56, 0.89] 3.3e-3 193
15 years 0.00 0.56 [0.42, 0.74] 6.3e-5 79
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_HYPTENSPREG – Hypertension complicating pregnancy, childbirth, and the puerperium
GWS hits: 8

Survival analyses between endpoints

Plot

before Hypertension complicating pregnancy, childbirth, and the puerperium
after Hypertension complicating pregnancy, childbirth, and the puerperium

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Drugs most likely to be purchased after Hypertension complicating pregnancy, childbirth, and the puerperium