Ischemic heart diseases

I9_ISCHHEART

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I20-I25

Cause of death: ICD-10 I20-I25

47365

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

47365

Check minimum number of events None

47365

Include endpoints

I9_ANGINA

I9_MI

I9_MI_STRICT

I9_MI_COMPLICATIONS

I9_POSTAMI

I9_CORATHER

I9_REVASC

50586

I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Ischemic heart diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

49030

17060

31970

Unadjusted prevalence (%)

15.89

9.83

23.68

Mean age at first event (years)

63.94

65.14

63.29

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Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.66 [3.37, 3.98]	<1e-100	13939
15 years	0.01	2.11 [1.93, 2.30]	1.0e-65	5458
5 years	0.00	3.58 [3.30, 3.88]	<1e-100	2885
1 year	0.00	26.25 [23.23, 29.67]	<1e-100	3979

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_ISCHHEART – Ischemic heart diseases
GWS hits: 39

Survival analyses between endpoints

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Plot

before Ischemic heart diseases
after Ischemic heart diseases

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Ischemic heart diseases

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