Ischemic heart diseases

I9_ISCHHEART

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I20-I25

Cause of death: ICD-10 I20-I25

47365

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

47365

Check minimum number of events None

47365

Include endpoints

I9_ANGINA

I9_MI

I9_MI_STRICT

I9_MI_COMPLICATIONS

I9_POSTAMI

I9_CORATHER

I9_REVASC

50586

I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Ischemic heart diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	49030	17060	31970
Unadjusted prevalence (%)	15.89	9.83	23.68
Mean age at first event (years)	63.94	65.14	63.29

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.66 [3.37, 3.98]	<1e-100	13939
15 years	0.01	2.11 [1.93, 2.30]	1.0e-65	5458
5 years	0.00	3.58 [3.30, 3.88]	<1e-100	2885
1 year	0.00	26.25 [23.23, 29.67]	<1e-100	3979

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_ISCHHEART – Ischemic heart diseases
GWS hits: 39

Survival analyses between endpoints

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Plot

before Ischemic heart diseases
after Ischemic heart diseases

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Ischemic heart diseases

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