Coronary atherosclerosis

I9_CORATHER

heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None

321302

diagram downward connector

Check conditions None

321302

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 I24, I25, T82.2, Z95.1
Hospital discharge: ICD-9 414|9960A
Hospital discharge: ICD-8 414
Hospital discharge: excluded ICD-10 I25.3
Cause of death: ICD-10 I24, I25, T82.2, Z95.1
Cause of death: ICD-9 414|9960A
Cause of death: ICD-8 414
Cause of death: excluded ICD-10 I25.3

37565

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

37565

diagram downward connector

Check minimum number of events None

37565

diagram downward connector

Include endpoints None

37565

diagram downward connector
I9_CORATHER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 36418 11350 25068
Unadjusted prevalence (%) 11.80 6.54 18.57
Mean age at first event (years) 66.97 68.17 66.43

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 4.00 [3.64, 4.38] <1e-100 11223
15 years 0.01 2.08 [1.89, 2.29] 6.5e-53 4046
5 years 0.00 3.89 [3.59, 4.22] <1e-100 2700
1 year 0.00 24.24 [21.74, 27.02] <1e-100 3734

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_CORATHER – Coronary atherosclerosis
GWS hits: 52

Survival analyses between endpoints

Plot

before Coronary atherosclerosis
after Coronary atherosclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Coronary atherosclerosis