Coronary atherosclerosis


heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 I24, I25, T82.2, Z95.1
Hospital discharge: ICD-9 414|9960A
Hospital discharge: ICD-8 414
Hospital discharge: excluded ICD-10 I25.3
Cause of death: ICD-10 I24, I25, T82.2, Z95.1
Cause of death: ICD-9 414|9960A
Cause of death: ICD-8 414
Cause of death: excluded ICD-10 I25.3


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 36418 11350 25068
Unadjusted prevalence (%) 11.80 6.54 18.57
Mean age at first event (years) 66.97 68.17 66.43


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 4.00 [3.64, 4.38] <1e-100 11223
15 years 0.01 2.08 [1.89, 2.29] 6.5e-53 4046
5 years 0.00 3.89 [3.59, 4.22] <1e-100 2700
1 year 0.00 24.24 [21.74, 27.02] <1e-100 3734

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_CORATHER – Coronary atherosclerosis
GWS hits: 52

Survival analyses between endpoints


before Coronary atherosclerosis
after Coronary atherosclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Coronary atherosclerosis