Coronary atherosclerosis

I9_CORATHER

heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I24, I25, T82.2, Z95.1

Hospital discharge: ICD-9 414|9960A

Hospital discharge: ICD-8 414

Hospital discharge: excluded ICD-10 I25.3

Cause of death: ICD-10 I24, I25, T82.2, Z95.1

Cause of death: ICD-9 414|9960A

Cause of death: ICD-8 414

Cause of death: excluded ICD-10 I25.3

37565

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

37565

Check minimum number of events None

37565

Include endpoints None

37565

I9_CORATHER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Coronary atherosclerosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	36418	11350	25068
Unadjusted prevalence (%)	11.80	6.54	18.57
Mean age at first event (years)	66.97	68.17	66.43

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.00 [3.64, 4.38]	<1e-100	11223
15 years	0.01	2.08 [1.89, 2.29]	6.5e-53	4046
5 years	0.00	3.89 [3.59, 4.22]	<1e-100	2700
1 year	0.00	24.24 [21.74, 27.02]	<1e-100	3734

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CORATHER – Coronary atherosclerosis
GWS hits: 52

Survival analyses between endpoints

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Plot

before Coronary atherosclerosis
after Coronary atherosclerosis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Coronary atherosclerosis

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