Angina pectoris

I9_ANGINA

Prinzmetal's angina: a syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel walls rather than directly by atherosclerosis (buildup of fatty plaque and hardening of the arteries). For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I20

Hospital discharge: ICD-9 413|411[0-1]

Hospital discharge: ICD-8 413

Cause of death: ICD-10 I20

Cause of death: ICD-9 413|411[0-1]

Cause of death: ICD-8 413

27932

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

27925

Check minimum number of events None

27925

Include endpoints None

27925

I9_ANGINA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 I20-I25

Name in latin Angina pectoris

Similar endpoints

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List of similar endpoints to Angina pectoris based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Unstable angina pectoris

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	27046	9267	17779
Unadjusted prevalence (%)	8.77	5.34	13.17
Mean age at first event (years)	62.78	63.89	62.19

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.10 [1.90, 2.34]	1.5e-44	7377
15 years	0.01	1.47 [1.34, 1.62]	9.3e-16	3760
5 years	0.00	2.17 [1.99, 2.36]	8.3e-69	1687
1 year	0.00	4.88 [4.31, 5.54]	<1e-100	753

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_ANGINA – Angina pectoris
GWS hits: 29

Survival analyses between endpoints

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Plot

before Angina pectoris
after Angina pectoris

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Table

Loading survival analyses table

Drugs most likely to be purchased after Angina pectoris

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