Ulcerative colitis

K11_ULCER

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K51

Hospital discharge: ICD-9 556

Hospital discharge: ICD-8 5631|569

Hospital discharge: excluded ICD-9 5564A

Cause of death: ICD-10 K51

Cause of death: ICD-9 556

Cause of death: ICD-8 5631|569

Cause of death: excluded ICD-9 5564A

7197

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6803

Check minimum number of events None

6803

Include endpoints None

6803

K11_ULCER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K50-K52

Name in latin Colitis ulcerosa

Similar endpoints

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List of similar endpoints to Ulcerative colitis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	6607	3485	3122
Unadjusted prevalence (%)	2.14	2.01	2.31
Mean age at first event (years)	42.60	40.76	44.66

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.74 [1.20, 2.51]	3.3e-3	456
15 years	0.01	1.11 [0.77, 1.60]	5.7e-1	201
5 years	0.00	1.98 [1.45, 2.71]	1.7e-5	96
1 year	0.00	5.50 [3.81, 7.95]	9.0e-20	50

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_ULCER – Ulcerative colitis
GWS hits: 12

Survival analyses between endpoints

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Plot

before Ulcerative colitis
after Ulcerative colitis

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Table

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Drugs most likely to be purchased after Ulcerative colitis

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