Inflammatory bowel disease

K11_IBD

inflammatory bowel disease: A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

8966

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K11_IBD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Inflammatory bowel disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 8704 4644 4060
Unadjusted prevalence (%) 2.82 2.68 3.01
Mean age at first event (years) 41.87 40.13 43.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.86 [1.49, 2.31] 2.5e-8 574
15 years 0.01 1.11 [0.90, 1.39] 3.3e-1 238
5 years 0.00 2.27 [1.77, 2.90] 9.1e-11 138
1 year 0.00 5.78 [4.27, 7.82] 5.8e-30 67

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_IBD – Inflammatory bowel disease
GWS hits: 19

Survival analyses between endpoints

Plot

before Inflammatory bowel disease
after Inflammatory bowel disease

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Drugs most likely to be purchased after Inflammatory bowel disease