Crohn disease

K11_CROHN

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K50

Hospital discharge: ICD-9 555

Hospital discharge: ICD-8 5630

Cause of death: ICD-10 K50

Cause of death: ICD-9 555

Cause of death: ICD-8 5630

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

3243

K11_CROHN

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K50-K52

Name in latin Morbus Crohn

Similar endpoints

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List of similar endpoints to Crohn disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3147	1746	1401
Unadjusted prevalence (%)	1.02	1.01	1.04
Mean age at first event (years)	42.54	41.00	44.46

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.79 [1.75, 4.43]	1.5e-5	155
15 years	0.01	1.49 [0.95, 2.34]	8.6e-2	61
5 years	0.00	4.13 [2.78, 6.12]	1.7e-12	50
1 year	0.00	8.65 [5.29, 14.13]	6.8e-18	23

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CROHN – Crohn disease
GWS hits: 4

Survival analyses between endpoints

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Plot

before Crohn disease
after Crohn disease

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Table

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Drugs most likely to be purchased after Crohn disease

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