Crohn disease


Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 K50
Hospital discharge: ICD-9 555
Hospital discharge: ICD-8 5630
Cause of death: ICD-10 K50
Cause of death: ICD-9 555
Cause of death: ICD-8 5630


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50-K52
Name in latin Morbus Crohn

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 3147 1746 1401
Unadjusted prevalence (%) 1.02 1.01 1.04
Mean age at first event (years) 42.54 41.00 44.46


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.79 [1.75, 4.43] 1.5e-5 155
15 years 0.01 1.49 [0.95, 2.34] 8.6e-2 61
5 years 0.00 4.13 [2.78, 6.12] 1.7e-12 50
1 year 0.00 8.65 [5.29, 14.13] 6.8e-18 23

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: K11_CROHN – Crohn disease
GWS hits: 4

Survival analyses between endpoints


before Crohn disease
after Crohn disease

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