Crohn disease (strict definition, require KELA, min 2 HDR)

K11_CD_STRICT2

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

K11_KELACROHN

and K11_CROHNnumber of events

1415

Filter registries

Hospital Discharge: ICD-10 K50

Hospital discharge: ICD-9 555

Hospital discharge: ICD-8 5630

Cause of death: ICD-10 K50

Cause of death: ICD-9 555

Cause of death: ICD-8 5630

1317

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1317

Check minimum number of events None

1317

Include endpoints None

1317

K11_CD_STRICT2

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF3

Parent code in ICD-10 K50-K52

Name in latin Morbus Crohn

Similar endpoints

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List of similar endpoints to Crohn disease (strict definition, require KELA, min 2 HDR) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Crohn's disease (strict) with PSC

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1282	743	539
Unadjusted prevalence (%)	0.42	0.43	0.40
Mean age at first event (years)	39.86	39.50	40.37

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.66 [0.85, 3.23]	1.4e-1	21
15 years	0.01	1.16 [0.57, 2.38]	6.8e-1	11
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CD_STRICT2 – Crohn disease (strict definition, require KELA, min 2 HDR)
GWS hits: 3

Survival analyses between endpoints

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Plot

before Crohn disease (strict definition, require KELA, min 2 HDR)
after Crohn disease (strict definition, require KELA, min 2 HDR)

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Table

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Drugs most likely to be purchased after Crohn disease (strict definition, require KELA, min 2 HDR)

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