Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50)

K11_KELACROHN

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

KELA reimbursements: KELA codes 208
KELA reimbursements: ICD-10 K50

6136

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Check pre-conditions, main-only, mode, ICD version None

1441

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Check minimum number of events None

1441

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Include endpoints

1441

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K11_KELACROHN

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 1400 805 595
Unadjusted prevalence (%) 0.45 0.46 0.44
Mean age at first event (years) 40.94 40.11 42.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.16 [0.61, 2.19] 6.5e-1 25
15 years 0.01 0.88 [0.46, 1.69] 7.0e-1 12
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_KELACROHN – Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50)
GWS hits: 4

Survival analyses between endpoints

Plot

before Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50)
after Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50)

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Drugs most likely to be purchased after Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50)