Crohn disease (strict definition, require KELA)

K11_CD_STRICT

ileocolitis: Ileocolitis or ileal Crohn's is the most common type of Crohn's disease. It affects both the ileum (small intestine) and the colon.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

K11_KELACROHN

1441

Filter registries

Hospital Discharge: ICD-10 K50

Hospital discharge: ICD-9 555

Hospital discharge: ICD-8 5630

Cause of death: ICD-10 K50

Cause of death: ICD-9 555

Cause of death: ICD-8 5630

1343

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1343

Check minimum number of events None

1343

Include endpoints None

1343

K11_CD_STRICT

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF3

Parent code in ICD-10 K50-K52

Name in latin Morbus Crohn

Similar endpoints

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List of similar endpoints to Crohn disease (strict definition, require KELA) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1307	755	552
Unadjusted prevalence (%)	0.42	0.44	0.41
Mean age at first event (years)	40.14	39.72	40.72

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.92 [0.94, 3.89]	7.1e-2	23
15 years	0.01	1.45 [0.73, 2.89]	2.9e-1	12
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CD_STRICT – Crohn disease (strict definition, require KELA)
GWS hits: 3

Survival analyses between endpoints

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Plot

before Crohn disease (strict definition, require KELA)
after Crohn disease (strict definition, require KELA)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Crohn disease (strict definition, require KELA)

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