Ulcerative colitis (strict definition, require KELA, min 2 HDR)

K11_UC_STRICT2

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

K11_KELAUC

and K11_ULCERnumber of events

4395

Filter registries

Hospital Discharge: ICD-10 K51

Hospital discharge: ICD-9 556

Hospital discharge: ICD-8 5631|569

Hospital discharge: excluded ICD-9 5564A

Cause of death: ICD-10 K51

Cause of death: ICD-9 556

Cause of death: ICD-8 5631|569

Cause of death: excluded ICD-9 5564A

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

3981

K11_UC_STRICT2

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF3

Parent code in ICD-10 K50-K52

Name in latin Colitis ulcerosa

Similar endpoints

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List of similar endpoints to Ulcerative colitis (strict definition, require KELA, min 2 HDR) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3868	2015	1853
Unadjusted prevalence (%)	1.25	1.16	1.37
Mean age at first event (years)	40.07	37.85	42.48

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.72 [0.45, 1.16]	1.7e-1	106
15 years	0.00	0.51 [0.32, 0.82]	5.9e-3	48
5 years	0.00	0.56 [0.28, 1.12]	1.0e-1	11
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_UC_STRICT2 – Ulcerative colitis (strict definition, require KELA, min 2 HDR)
GWS hits: 13

Survival analyses between endpoints

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Plot

before Ulcerative colitis (strict definition, require KELA, min 2 HDR)
after Ulcerative colitis (strict definition, require KELA, min 2 HDR)

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Table

Loading survival analyses table

Drugs most likely to be purchased after Ulcerative colitis (strict definition, require KELA, min 2 HDR)

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