Ulcerative colitis, NAS

ULCERNAS

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K51.9

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K51.9

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

3552

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3552

Check minimum number of events None

3552

Include endpoints None

3552

ULCERNAS

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K51

Name in latin Colitis ulcerosa non specificata

Similar endpoints

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List of similar endpoints to Ulcerative colitis, NAS based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3438	1882	1556
Unadjusted prevalence (%)	1.11	1.08	1.15
Mean age at first event (years)	46.30	44.49	48.48

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.33 [1.49, 3.64]	2.1e-4	221
15 years	0.01	1.29 [0.82, 2.00]	2.7e-1	96
5 years	0.00	2.75 [1.86, 4.05]	3.6e-7	59
1 year	0.00	10.23 [6.79, 15.42]	1.2e-28	42

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ULCERNAS – Ulcerative colitis, NAS
GWS hits: 5

Survival analyses between endpoints

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Plot

before Ulcerative colitis, NAS
after Ulcerative colitis, NAS

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Table

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Drugs most likely to be purchased after Ulcerative colitis, NAS

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