Fibrosis and chirrhosis of liver

K11_FIBROCHIRLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K74

Hospital discharge: ICD-9 571[5-6]

Hospital discharge: ICD-8 5719

Cause of death: ICD-10 K74

Cause of death: ICD-9 571[5-6]

Cause of death: ICD-8 5719

1462

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1403

Check minimum number of events None

1403

Include endpoints None

1403

K11_FIBROCHIRLIV

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K70-K77

Name in latin Fibrosis et cirrhosis hepatis

Similar endpoints

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List of similar endpoints to Fibrosis and chirrhosis of liver based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1362	730	632
Unadjusted prevalence (%)	0.44	0.42	0.47
Mean age at first event (years)	59.42	56.95	62.27

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_FIBROCHIRLIV – Fibrosis and chirrhosis of liver
GWS hits: 3

Survival analyses between endpoints

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Plot

before Fibrosis and chirrhosis of liver
after Fibrosis and chirrhosis of liver

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Table

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Drugs most likely to be purchased after Fibrosis and chirrhosis of liver

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