Biliary chirrosis, NAS

CHIRBIL_NAS

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K74.5

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K74.5

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

CHIRBIL_NAS

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K74

Name in latin Cirrhosis biliaris non specificata

Similar endpoints

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List of similar endpoints to Biliary chirrosis, NAS based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	65	43	22
Unadjusted prevalence (%)	0.02	0.02	0.02
Mean age at first event (years)	61.24	59.78	64.10

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHIRBIL_NAS – Biliary chirrosis, NAS
GWS hits:

Survival analyses between endpoints

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Plot

before Biliary chirrosis, NAS
after Biliary chirrosis, NAS

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Table

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Drugs most likely to be purchased after Biliary chirrosis, NAS

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