Diseases of liver

DOID EFO MESH SNOMED PheWeb

K11_LIVER

liver disease: A disease involving the liver.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K70-K77, K77.0*B96.8

Cause of death: ICD-10 K70-K77, K77.0*B96.8

7646

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

7646

Check minimum number of events None

7646

Include endpoints

K11_ALCOLIV

K11_TOXLIV

K11_HEPFAIL

K11_CHRONHEP

K11_FIBROCHIRLIV

K11_OTHINFLIV

K11_DISLIVOTH

K11_LIVDISINOTH

8419

K11_LIVER

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diseases of liver based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	8140	4003	4137
Unadjusted prevalence (%)	2.64	2.31	3.06
Mean age at first event (years)	53.18	51.93	54.39

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	5.75 [4.64, 7.11]	5.6e-58	1559
15 years	0.01	2.05 [1.68, 2.49]	8.7e-13	395
5 years	0.01	5.85 [4.94, 6.92]	5.2e-94	368
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_LIVER – Diseases of liver
GWS hits: 5

Survival analyses between endpoints

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Plot

before Diseases of liver
after Diseases of liver

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Table

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Drugs most likely to be purchased after Diseases of liver

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