Nonalcoholic fatty liver disease

NAFLD

non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K76.0

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K76.0

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1640

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1640

Check minimum number of events None

1640

Include endpoints None

1640

NAFLD

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K76

Name in latin Degeneratio adiposa hepatis non alibi classificata

Similar endpoints

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List of similar endpoints to Nonalcoholic fatty liver disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1578	876	702
Unadjusted prevalence (%)	0.51	0.50	0.52
Mean age at first event (years)	53.29	54.36	51.96

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.13	10.88 [7.66, 15.45]	1.4e-40	98
15 years	0.03	5.07 [3.50, 7.34]	9.6e-18	45
5 years	0.01	5.74 [3.45, 9.55]	1.8e-11	30
1 year	0.00	16.98 [9.42, 30.61]	4.4e-21	19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: NAFLD – Nonalcoholic fatty liver disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Nonalcoholic fatty liver disease
after Nonalcoholic fatty liver disease

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Table

Loading survival analyses table

Drugs most likely to be purchased after Nonalcoholic fatty liver disease

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