Alcoholic liver disease

ALCOLIVER

Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K70

Hospital discharge: ICD-9 571[0-3]

Hospital discharge: ICD-8 5710

Cause of death: ICD-10 K70

Cause of death: ICD-9 571[0-3]

Cause of death: ICD-8 5710

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

2206

ALCOLIVER

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K70-K77

Name in latin Morbus hepatis alcoholicus

Similar endpoints

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List of similar endpoints to Alcoholic liver disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Alcoholic liver disease

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2153	532	1621
Unadjusted prevalence (%)	0.70	0.31	1.20
Mean age at first event (years)	56.62	54.26	57.40

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ALCOLIVER – Alcoholic liver disease
GWS hits: 1

Survival analyses between endpoints

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Plot

before Alcoholic liver disease
after Alcoholic liver disease

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Table

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Drugs most likely to be purchased after Alcoholic liver disease

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