Fibrosis of liver

FIBROLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K74.0

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K74.0

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

115

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

115

Check minimum number of events None

115

Include endpoints None

115

FIBROLIV

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K74

Name in latin Fibrosis hepatis

Similar endpoints

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List of similar endpoints to Fibrosis of liver based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	111	64	47
Unadjusted prevalence (%)	0.04	0.04	0.03
Mean age at first event (years)	54.32	53.20	55.84

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: FIBROLIV – Fibrosis of liver
GWS hits: 0

Survival analyses between endpoints

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Plot

before Fibrosis of liver
after Fibrosis of liver

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Fibrosis of liver

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