Fibrosis and sclerosis of liver

FIBROSCLEROLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K74.2

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K74.2

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

FIBROSCLEROLIV

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K74

Name in latin Fibrosis et sclerosis hepatis

Similar endpoints

↥

List of similar endpoints to Fibrosis and sclerosis of liver based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	21	16	5
Unadjusted prevalence (%)	0.01	0.01	0.00
Mean age at first event (years)	51.81	51.27	53.53

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: FIBROSCLEROLIV – Fibrosis and sclerosis of liver
GWS hits:

Survival analyses between endpoints

↥

Plot

before Fibrosis and sclerosis of liver
after Fibrosis and sclerosis of liver

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Fibrosis and sclerosis of liver

↥