Primary biliary cholangitis (PBC)

CHIRBIL_PRIM

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K74.3

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K74.3

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

448

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

448

Check minimum number of events None

448

Include endpoints None

448

CHIRBIL_PRIM

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K74

Name in latin Cirrhosis biliaris [primaria]

Similar endpoints

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List of similar endpoints to Primary biliary cholangitis (PBC) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	433	361	72
Unadjusted prevalence (%)	0.14	0.21	0.05
Mean age at first event (years)	55.88	55.28	58.88

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.74 [0.58, 5.20]	3.2e-1	38
15 years	0.01	1.06 [0.34, 3.30]	9.2e-1	17
5 years	0.00	3.03 [1.18, 7.79]	2.2e-2	12
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits: 0

Survival analyses between endpoints

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Plot

before Primary biliary cholangitis (PBC)
after Primary biliary cholangitis (PBC)

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Table

Loading survival analyses table

Drugs most likely to be purchased after Primary biliary cholangitis (PBC)

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