Primary biliary cholangitis (PBC)

CHIRBIL_PRIM

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 K74.3
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K74.3
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

448

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

448

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Check minimum number of events None

448

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Include endpoints None

448

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CHIRBIL_PRIM

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Cirrhosis biliaris [primaria]

Summary Statistics

Key figures

All Female Male
Number of individuals 433 361 72
Unadjusted prevalence (%) 0.14 0.21 0.05
Mean age at first event (years) 55.88 55.28 58.88

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.74 [0.58, 5.20] 3.2e-1 38
15 years 0.01 1.06 [0.34, 3.30] 9.2e-1 17
5 years 0.00 3.03 [1.18, 7.79] 2.2e-2 12
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits: 0

Survival analyses between endpoints

Plot

before Primary biliary cholangitis (PBC)
after Primary biliary cholangitis (PBC)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Primary biliary cholangitis (PBC)