Primary biliary cholangitis (PBC)


primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 K74.3
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K74.3
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Cirrhosis biliaris [primaria]

Summary Statistics

Key figures

All Female Male
Number of individuals 433 361 72
Unadjusted prevalence (%) 0.14 0.21 0.05
Mean age at first event (years) 55.88 55.28 58.88


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.74 [0.58, 5.20] 3.2e-1 38
15 years 0.01 1.06 [0.34, 3.30] 9.2e-1 17
5 years 0.00 3.03 [1.18, 7.79] 2.2e-2 12
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits: 0

Survival analyses between endpoints


before Primary biliary cholangitis (PBC)
after Primary biliary cholangitis (PBC)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Primary biliary cholangitis (PBC)