Valvular heart disease excluding rheumatic fever

I9_VHD

heart valve disease: A disease involving the cardial valve.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

64352

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I9_VHD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 62218 29874 32344
Unadjusted prevalence (%) 20.16 17.22 23.95
Mean age at first event (years) 61.15 59.55 62.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.34 [3.01, 3.70] <1e-100 7103
15 years 0.01 1.65 [1.49, 1.84] 1.3e-20 2778
5 years 0.00 3.57 [3.28, 3.88] <1e-100 2578
1 year 0.00 9.79 [8.77, 10.94] <1e-100 1504

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_VHD – Valvular heart disease excluding rheumatic fever
GWS hits: 12

Survival analyses between endpoints

Plot

before Valvular heart disease excluding rheumatic fever
after Valvular heart disease excluding rheumatic fever

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Drugs most likely to be purchased after Valvular heart disease excluding rheumatic fever